THE CELL a Molecular Approach

FULL CONTENTS

Preface
Organization and Features of The Cell
Acknowledgments
I. Introduction
1. An Overview of Cells and Cell Research
The Origin and Evolution of Cells
Cells As Experimental Models
Tools of Cell Biology
Summary
Questions
References and Further Reading
2. The Chemistry of Cells
The Molecular Composition of Cells
The Central Role of Enzymes as Biological Catalysts
Metabolic Energy
The Biosynthesis of Cell Constituents
Cell Membranes
Summary
Questions
References and Further Reading
3. Fundamentals of Molecular Biology
Heredity, Genes, and DNA
Expression of Genetic Information
Recombinant DNA
Detection of Nucleic Acids and Proteins
Gene Function in Eukaryotes
Summary
Questions
References and Further Reading
II. The Flow of Genetic Information
4. The Organization of Cellular Genomes
The Complexity of Eukaryotic Genomes
Chromosomes and Chromatin
The Sequences of Complete Genomes
The Human Genome
Summary
Questions
References and Further Reading
5. Replication, Maintenance, and Rearrangements of Genomic DNA
DNA Replication
DNA Repair
Recombination Between Homologous DNA Sequences
DNA Rearrangements
Summary
Questions
References and Further Reading
6. RNA Synthesis and Processing
Transcription in Prokaryotes
Eukaryotic RNA Polymerases and General Transcription Factors
Regulation of Transcription in Eukaryotes
RNA Processing and Turnover
Summary
Questions
References and Further Reading
7. Protein Synthesis, Processing, and Regulation
Translation of mRNA
Protein Folding and Processing
Regulation of Protein Function
Protein Degradation
Summary
Questions
References and Further Reading
III. Cell Structure and Function
8. The Nucleus
The Nuclear Envelope and Traffic between the Nucleus and Cytoplasm
Internal Organization of the Nucleus
The Nucleolus
The Nucleus during Mitosis
Summary
Questions
References and Further Reading
9. Protein Sorting and Transport – The Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes
The Endoplasmic Reticulum
The Golgi Apparatus
The Mechanism of Vesicular Transport
Lysosomes
Summary
Questions
References and Further Reading
10. Bioenergetics and Metabolism – Mitochondria, Chloroplasts, and Peroxisomes
Mitochondria
The Mechanism of Oxidative Phosphorylation
Chloroplasts and Other Plastids
Photosynthesis
Peroxisomes
Summary
Questions
References and Further Reading
11. The Cytoskeleton and Cell Movement
Structure and Organization of Actin Filaments
Actin, Myosin, and Cell Movement
Intermediate Filaments
Microtubules
Microtubule Motors and Movements
Summary
Questions
References and Further Reading
12. The Cell Surface
Structure of the Plasma Membrane
Transport of Small Molecules
Endocytosis
Cell Walls and the Extracellular Matrix
Cell-Cell Interactions
Summary
Questions
References and Further Reading
IV. Cell Regulation
13. Cell Signaling
Signaling Molecules and Their Receptors
Functions of Cell Surface Receptors
Pathways of Intracellular Signal Transduction
Signal Transduction and the Cytoskeleton
Signaling in Development and Differentiation
Regulation of Programmed Cell Death
Summary
Questions
References and Further Reading
14. The Cell Cycle
The Eukaryotic Cell Cycle
Regulators of Cell Cycle Progression
The Events of M Phase
Meiosis and Fertilization
Cell Proliferation in Development and Differentiation
Summary
Questions
References and Further Reading
15. Cancer
The Development and Causes of Cancer
Tumor Viruses
Oncogenes
Tumor Suppressor Genes
Applications of Molecular Biology to Cancer Prevention and Treatment
Summary
Questions
References and Further Reading
Answers to Questions

Glossary

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