1. Repetitive DNA sequences were first identified by studies of rates of DNA reassociation. What relative rates of reassociation are expected for sequences repeated 1000 times in the genome compared to genes with only a single copy?

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2. How many histone molecules are associated with the chromosomes of a human cell? Assuming that a typical cell contains about 1 ng of protein, what fraction of total cellular protein corresponds to histones?

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3. Why are YAC vectors useful for analysis of complex genomes? What is the role of telomeres in these vectors?

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4. Assuming that yeast and C. elegans utilize a similar number of proteins to carry out basic cellular functions, what fraction of C. elegans genes are expected to encode proteins involved in aspects of cell regulation specific to multicellular organisms?

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5. Approximately 30,000 cDNAs have been localized on the human genome map. What is the average distance between these markers?

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